Radiation sensitivity of human bone marrow fibroblast colony forming unit (CFU-F) to various radiation sources.
نویسندگان
چکیده
منابع مشابه
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny.
The bone marrow stromal cell population is comprised of fibroblasts, endothellal cells, fat cells and “reticular cells.” The characteristics and the regulatory role in hematopolesis of each of these cell types are unknown. A liquid culture system has been used to clone and to characterize human bone marrow fibroblast colony-forming cells (CFU-F). The linear relationship between the number of ce...
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Increasing evidence especially stemming from peripheral blood progenitor transplantation studies points to a possible biologic difference between mobilized blood and bone marrow progenitor cells. The objective of this study was to compare the in situ radiation sensitivity of recombinant human granulocyte colony-stimulating factor (rhG-CSF)-recruited circulating granulopoietic (blood colony-form...
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A chromosome analysis was performed on cultured bone marrow fibroblasts (CFU-F) from two atomic bomb survivors exposed within 1 km of the hypocenter, whose estimated radiation dose is 357 rad and 365 rad respectively. In CFU-F of both cases, stable types of chromosome aberrations were detected. The rate of these chromosome aberrations related well to the chromosome aberration rate of peripheral...
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Chronic myeloproliferative disorders (MPD) are clonal diseases of the pluripotent hematopoietic stem cell frequently associated with myelofibrosis (MF). There is only indirect evidence indicating that the increased deposition of collagen in bone marrow matrix is a secondary phenomenon. A liquid culture system for cloning and growing bone marrow fibroblasts has permitted us to approach more dire...
متن کاملpluripoietin, supports colony formation of normal human bone marrow in vitro from muitipotential (colony forming unit of granulocytes/erythrocytes/macrophages/megakaryocytes [CFU-GEMM]) and early erythroid (burst forming unit of erythroid cells [BFU-E]) progenitors, as
Colony stimulating factors (CSF) 1 a r e a class of hemopoietic regulatory glycoproteins required for survival, proliferation, and differentiation of hemopoietic stem and progenitor cells in vitro, and probably in vivo (1, 2). Many efforts have been undertaken to characterize the biochemical and biological properties of these factors. In the routine system, CSF stimulating the growth of progeni...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 1988
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.29.182